Case 7 Female, 5 years. Skin lesion, upper armShow diagnosis & comments
Spitz naevus, Kamino bodies.
KAMINO BODIES are solitary rounded or confluent, amorphous, eosinophilic masses of basement membrane material, found at the dermoepidermal junction, most commonly at the tips of dermal papillae, in some Spitz naevi and, far less commonly, other benign and malignant melanocytic proliferations.
Clusters of Kamino bodies are so much more common in Spitz naevi than in other lesions, that they form an important diagnostic clue. However, their presence does not rule out melanoma completely, since a rare melanoma contains similar clustered Kamino bodies.
In H&E sections, Kamino bodies show some resemblance to Civatte bodies, as can be found in lichen planus, but the letter represent apoptotic cell remnants, whereas Kamino bodies consist of extracellular matrix components.