Case 5B Female, 1 ½ years. Recurrent papule, cheek. S-100 immune stain of the lesion shown in case 5A.Show diagnosis & comments
(Recurrent) Spitz naevus.
An immune stain such as S-100 or MART-1 (Melan-A) helps in reviewing the overall architecture, which in Spitz naevus tends to be very regular, contrasting with most melanomas of similar thickness, which tend to show more variability in cellular features, arrangement of lesional cells, and reactive changes.