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Clinical information

Case 16 Male, 38 years. Suspicious skin nodule, lower leg

Show diagnosis & comments

Diagnosis:

Superficial spreading melanoma.

Comments:

Note the abrupt changes in cell type from area to area. Some melanoma cell groups show a naevoid (monomorphous, small cell) phenotype. It is very obvious here, but to a lesser extent this phenomenon is commonly present in melanoma. Probably it reflects the genetic instability of melanoma, with outgrowth of subclones that differ genotypically, and therefore phenotypically, from each other. Some of this variability is even visible macroscopically (variations in colour, contour, raised or flat aeras, focal regression), forming important clinical clues that the lesion is a melanoma.

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Dear {friend_name}, {url} I believe this website may be of interest to you. It is an Open Educational Resource, containing a large collection of digitized histologic slides with explanatory films and other materials, aimed at surgical pathologists, dermatopathologist and pathologists in training. This site is entirely based on consultation materials of professor Wolter Mooi, VU University Amsterdam, and can be used free of charge. Kind regards, {my_name}

Slide sets

  • Common acquired naevus
  • Spitz naevus and variants
  • Blue naevus and variants
  • Congenital naevus
  • Dysplastic naevus
  • Nonmelanocytic skin lesions; some DD's
  • Melanoma: general features
  • Melanoma subtypes
  • Extracutaneous melanocytic lesions
  • Extracutaneous nonmelanocytic pigmented lesions
  • Problems and pitfalls

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